Initial Transcribed Sequence Mutations Specifically Affect Promoter Escape Properties
نویسندگان
چکیده
منابع مشابه
Complete sequence of the rat CYP2A3 gene specifically transcribed in lung.
The rat CYP2A subfamily is composed of three members designated CYP2A1, CYP2A2 and CYP2A3. The CYP2A1 gene is expressed in livers of female rats and is transiently expressed in young males then expression is extinguished when male rats reach puberty (1). The CYP2A2 gene is expressed in livers of postpubertal male rats but is not expressed in females at any stage of development (1). Both genes h...
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The mechanism leading to increased production of staphylococcal enterotoxin type A (SEA) in mutant Staphylococcus aureus FRI722 compared within its wild-type parent strain, FRI100, was examined. Sequence analysis revealed two mutations in the upstream promoter region of FRI722 at nucleotides -28 and +3 with respect to the transcriptional initiation site at An sea translational fusion of the ups...
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The phenotypic defects of two type 1 Mahoney poliovirus mutants, termed VP1-101 and VP1-102, were caused by two different small deletions in the region of the RNA genome encoding the amino terminus of the capsid protein VP1. This portion of VP1 was unresolved in the three-dimensional structure of the poliovirion, buried within the virion, and likely to interact with the viral RNA. Both VP1-101 ...
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We aim to explore if RNA regulating gene expression is affected by length, sequence and position of RNA. HeLa cells were co-transfected with modulator plasmids (derived from pcDNA3.1 vector containing different length regulating sequences that produce RNAs) and reporter plasmids (derived from pEGFP-C1 vector); In addition, HeLa cells were transfected with plasmids that possess different sequenc...
متن کاملInitial transcribed region sequences influence the composition and functional properties of the bacterial elongation complex.
The bacterial RNA polymerase (RNAP) holoenzyme consists of a catalytic core enzyme (α(2)ββ'ω) in complex with a σ factor that is essential for promoter recognition and transcription initiation. During early elongation, the stability of interactions between σ and the remainder of the transcription complex decreases. Nevertheless, there is no mechanistic requirement for release of σ upon the tran...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2006
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi060247u